منابع مشابه
Cell Stress Proteins in Atherothrombosis
Cell stress proteins (CSPS) are a large and heterogeneous family of proteins, sharing two main characteristics: their levels and/or location are modified under stress and most of them can exert a chaperon function inside the cells. Nonetheless, they are also involved in the modulation of several mechanisms, both at the intracellular and the extracellular compartments. There are more than 100 pr...
متن کاملInflammation-sensitive proteins and erythrocyte aggregation in atherothrombosis.
OBJECTIVE To find the relative contribution of various inflammation-sensitive proteins including fibrinogen, immunoglobulins (IgG, IgM and IgA), ceruloplasmin and high sensitivity C-reactive protein (hs-CRP) to the induction and/or maintenance of enhanced erythrocyte adhesiveness/aggregation in the peripheral blood of individuals with atherothrombotic risk factors. METHODS The degree of eryth...
متن کاملRole of oxidative stress and nitric oxide in atherothrombosis.
During the last decade basic and clinical research has highlighted the central role of reactive oxygen species (ROS) in cardiovascular disease. Enhanced production or attenuated degradation of ROS leads to oxidative stress, a process that affects endothelial and vascular function, and contributes to vascular disease. Nitric oxide (NO), a product of the normal endothelium, is a principal determi...
متن کاملOxidative Stress in Human Atherothrombosis: Sources, Markers and Therapeutic Targets
Atherothrombosis remains one of the main causes of morbidity and mortality worldwide. The underlying pathology is a chronic pathological vascular remodeling of the arterial wall involving several pathways, including oxidative stress. Cellular and animal studies have provided compelling evidence of the direct role of oxidative stress in atherothrombosis, but such a relationship is not clearly es...
متن کاملTargeting T cell costimulation to prevent atherothrombosis.
Inflammation plays a key role in atherogenesis and precipitation of atherothrombosis. Immune cells, including macrophages and T cells, infiltrate the affected vascular wall, and inflammation drives build-up of atherosclerotic plaques.1–3 This concept of immune activation in atherosclerosis has become accepted, but specific therapy directed at inflammatory mechanisms is yet lacking.4 T cell acti...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2012
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2012/232464